Dietary Supplements + Birch Bark Extract
How Birch Bark Extract can be used in Dietary Supplements

Birchula™ Methods of Action
Scientifically proven benefits of birch bark extract
• Reduces inflammation B, BA, L
• Triggers the release of GLP-1 BA
• Controls carbohydrate metabolism BBE
• Anti-oxidant B, BA, L
• Controls blood sugars B, BA, L
• Improves glucose uptake B
• Reduces cholesterol B, L
• Lowers cardiac lipid levels B
(B) Betulin, (BA) betulinic acid, (L) lupeol, (BBE) birch bark extract
Positive impact of birch bark triterpenes on carbohydrate metabolism
- Betulinic Acid inhibits PTP1B improving sensitivity to leptin, an anti-obesity hormone.(1)
- Betulinic acid promotes energy expenditure by triggering the release of GLP-1 (10,11)
- Betulin stimulates glucose uptake at about 20% of the effect of Insulin. (12)
- Betulinic Acid impedes the breakdown of complex carbohydrates into simple sugars (12,13)
Birch bark triterpenes affect lipid metabolism and modification
- Betulinic Acid restricts fatty acid uptake from food2
- Lupeol inhibits the fatty acid synthase enzyme3
- Betulinic Acid promotes lipid breakdown by inhibiting cAMP-dependent phosphodiesterase4
- Betulin and Betulinic Acid inhibits sterol regulatory element binding proteins (SREBP) improving hyperlipidemia, insulin resistance and reducing atherosclerotic plaque.5, 6
- Betulinic acid promotes the efflux of lipid from these foam cells reducing the risk of atherosclerosis7
- Birch bark triterpenes inhibit the oxidation of “bad” low-density lipoprotein to form oxLDL8, which contributes to atherosclerotic plaque formation9
Key Areas That Benefit from Birchula™
Why Choose Us
At The Actives Factory, we understand the critical importance of maintaining a healthy cardiovascular and metabolic system. Our Cardiometabolic Health solutions leverage the powerful benefits of Birchula™ Birch Bark Extract to support heart health, regulate blood sugar levels, and combat inflammation. Here’s why we stand out.
Scientifically Supported Benefits
Our products are backed by extensive research, targeting key mechanisms to reduce cardiovascular risks and promote metabolic balance.
Natural and Sustainable
Birchula™ is sustainably sourced and processed, ensuring safe and eco-friendly solutions for your health.
Innovative Expertise
With proprietary formulations, we deliver effective and reliable products tailored to improve your cardiometabolic health.
Commitment to Wellness
Our mission is to empower individuals with natural, science-driven solutions that make a real difference in their lives.